Genetic Mutation through MTHFR

MTHFR stands for methylenetetrahydrofolatereductase and is an enzyme that breaks down the amino acids’ homocysteine and folate. An MTHFR gene mutation can affect how your body do metabolises and converts nutrients from the food into different active vitamins, minerals, and proteins. This genetic mutation may also affect hormone and neurotransmitter levels, brain function, digestion, cholesterol levels, and many other things.


Types of MTHFR Mutations:

The C677T and A1298C variants are the most frequent MTHFR mutations.

The 677C>T polymorphism is found in both copies of the gene in around 25% of Hispanics and 10% to 15% of North American whites. The majority of persons who have MTHFR gene polymorphisms do not have neural tube anomalies, and their offspring are usually unaffected as well.A gene variant is a change in a DNA form that is different from the anticipated DNA sequence. The MTHFR gene instructs your body to produce the MTHFR protein, which aids in the absorption of folate. Folate is required for the production of DNA and the modification of proteins in your body.

A person with a deficiency of a protein involved in the metabolism of folate and sulfur-containing amino acids has been diagnosed with a potentially life-threatening condition called 5, 10-Methylene-tetrahydrofolate reductase (MTHFR) deficiency.It can cause certain cancers, birth defects and auto-immune diseases.


Complications in Pregnancy:

MTHFR gene mutation increase risk factor of complications in pregnancy. Genes passed from both parents i.e., mother and father. Each of your kid can get one copy of MTHFR gene. It may increase the risk factor of blood clotting.



MTHFR mutations are associated with the metabolic dysfunction.

It may cause:

  • Brain disorders such as mental illness, Anxiety, depression
  • Hair thinning or hair loss
  • Hypothyroidism


Worse Gene:

People who are having two copies may have high risk of children having neural tube defects. It may lower vitamin-D levels. It may have higher risk for miscarriages. MTHFR associated with premature delivery. It may pass from one generation to other generation.


Avoid Supplements:

Avoid bread, cereals, and commercially produced flours. Processed foods containing synthetic folic acid should be avoided.Avoid food contains rancid oils, hydrogenated fats, refined sugar and corn syrup.

Do not drink alcohol with MTHFR gene mutation. In people with MTHFR genetic abnormalities, limiting alcohol consumption can help to promote less interference in already stunted methylation activities. Alcohol intake should be consumed in moderation, and preferably in the forms of tequila, vodka, and mescal, rather than wine and beer.



MTHFR mutations may make it more difficult to convert folic acid into a useful form. It’s critical to choose a folate supplement that provides the highest bioavailable form. Magnesium, vitamin D, and vitamin B6 are other vitamins that can assist support this genetic variation. MTHFR diagnosed early and betaine treatment started right away. Vitamins b6 and b12 may be used toeat a high fiber diet (30-50g per day) and remove all refined sugars from your diet. Regularly move and sweat, at least 4-5 times a week, with regular sauna treatments and Epsom salt baths. Utilize particular supplements that aid in detoxification, such as antioxidants, fibre, and phytonutrients.


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